Last 5 Years PYQs INI-CET Biochemistry

Q1. What is true about the Hayflick limit?

1. Human cells can divide a finite number of times only
2. Free radical oxidation level is unrestricted
3. Telomerase activity is restricted.
4. RNA polymerase can function for a finite amount of time only

Ans. 1) Human cells can divide a finite number of times only

Q2. DNA methylation not related to?

1. Mismatch repair
2. Chromatin remodeling
3. DNA replication
4. Gene silencing

Ans. 3) DNA replication

Q3. The correct order of steps in a polymerase chain reaction (PCR) is:

1. Hybridization, annealing, elongation, denaturation
2. Elongation, denaturation, Hybridization, annealing,
3. Denaturation, annealing, extension.
4. Annealing, extension, denaturation

Ans. 3) Denaturation, annealing, extension

Also read: Biochemistry Important Questions For NEET PG/FMG Exams

Q4. The meal that exhibits the highest thermic effect is characterized by

1. Protein
2. Fat
3. Carbohydrates
4. Mixed meal having all 3 in equal amount

Ans. 1) Protein

Q5. The sequence of vitamin D synthesis is?

1. Liver-skin-kidney
2. Skin-liver-kidney
3. Skin-kidney-liver
4. Liver-kidney-skin

Ans. 2) Skin-liver-kidney

Q6. How does RNAi impact gene expression?

1. Knock out
2. Knockdown
3. Knock up
4. Knock in

Ans. 2) Knockdown

Q7. Which of the following poisoning agents does not inhibit cytochrome oxidase?

1. Hydrogen sulfide
2. Carbon monoxide
3. Methane
4. Cyanide

Ans. 3) Carbon monoxide

Also read: Important Questions On Carbohydrate Chemistry

Q8. Which of the following lipase enzymes is inhibited by the insulin?

1. Lipoprotein lipase
2. Pancreatic lipase
3. Gastric lipase
4. Hormone-sensitive lipase

Ans. 4) Hormone sensitive lipase

Q9. What is the main substrate and metabolic fuel used by RBCs during fasting period?

1. Ketone bodies
2. Glucose
3. Free fatty acids
4. Amino acids

Ans. 2) Glucose

Q10. Which of the following diagnostic markers is/are not correctly matched?

1. Beta-glucocerebrosidase	Von Gierke disease
2. Lipase	Acute pancreatitis
3. Ceruloplasmin	Hepatolenticular degeneration
4. High LDH1: LDH2 ratio	Myocardial infarction

1. 1 only
2. 1 and 2
3. 1, 2 and 4
4. 2, 3 and 4

Ans. 1) 1 only

Q11. In a patient with maple syrup urine disease, all of the following amino acids should be restricted in diet, except?

1. Methionine
2. Valine
3. Leucine
4. Isoleucine

Ans. 1) Methionine

Also read: Last 5 year PYQs in Psychiatry  for NEET PG

Q12. Affinity maturation of antibodies is because of ____.

1. Somatic hypermutation
2. Differential mRNA processing
3. CD40
4. Gene rearrangements

Ans. 1) Somatic hypermutation

Q13. The best method for the detection of mutations with low allele frequency is:

1. Droplet digital PCR
2. FISH
3. Nested PCR
4. Sanger sequencing

Ans. 1) Droplet digital PCR

Q14. Deamination of methylated cytosine forms which of the following?

1. Uracil
2. Cytosine
3. Guanine
4. Thymine​

 Ans. 4) Thymine

Also read: Important Topics in Biochemistry for NEET-PG

Q15. Which of the following options best describes the mutation seen in patients with cystic fibrosis?

1. Tryptophan at 708 position, chloride channel
2. Phenylalanine at 708 position, calcium channel
3. Phenylalanine at 508 position, chloride channel
4. Tryptophan at 508 position, calcium channel

​Ans. 3) Phenylalanine at 508 position, chloride channel

Q16. Which of the following enzyme defects leads to Pompe’s disease?

1. Lysosomal acid alpha glucosidase
2. β-hexosaminidase-A
3. Β–galactocerebrosidase
4. β-glucocerebrosidase

Ans. 1) Lysosomal acid alpha glucosidase

Q17. Xanthurenic aciduria may be treated with high doses of which vitamin

1. Vitamin B6
2. Vitamin B12
3. Vitamin B5
4. Vitamin B7

Ans. 1) Vitamin B6

Also read: Last 5 Year PYQs in ENT for NEET PG

Q18. Deficiency of which of the following causes Barth syndrome?

1. Cardiolipin
2. Sphingomyelin
3. Glycolipids
4. Cerebroside

Ans. 1) Cardiolipin

Q19. What determines the DNA sequence?

1. Flow cytometry
2. FISH
3. RFLP
4. PCR

Ans. 4) PCR

Q20. Calculate Anion Gap ?

Na: 145 mmol/L

K: 4 mmol/L

CI: 90 mmol/L

HCO3 : 15mmol/L

1. 35
2. 40
3. 28
4. 12

Ans. 2) 40

Also read: Last 5 Years PYQs of INI CET Dermatology

Q21. Ketosis is common in type 1 DM due to: 

• Decreased beta-oxidation of fatty acids
• Increased mobilization of fat from the adipose cell
• Decreased acetyl CoA in TCA cycle
• Increase beta-hydroxy butyryl synthase

1. 1, 2, and 3
2. 1, 2, 3, and 4
3. 4 only
4. 1 and 2 only

Ans. 1) 1, 2, and 3

Q22. Which type of DNA repair mechanism involves the removal and replacement of a damaged DNA strand with the help of an undamaged complementary strand as a template?

1. Base Excision Repair
2. Nucleotide Excision Repair
3. Mismatch Repair
4. Homologous Recombination

Ans. 4) Homologous Recombination

Q23. What is the enzyme that is shared by both glycolysis and gluconeogenesis?

1. Pyruvate kinase
2. Phosphofructokinase
3. Phosphoenolpyruvate carboxy kinase
4. Phosphoglycerate kinase

Ans. 4) Phosphoglycerate Kinase

Also read: Last 5 Year PYQs in Pathology for NEET PG​

Q24. Out of the enzymes listed below, which one exhibits the greatest catalytic efficiency?

1. Km of an enzyme = 10 micromole and Kcat = 20 per sec
2. Km of an enzyme = 2000 nanomole and Kcat = 50 per sec
3. Km of an enzyme = 2 micromole and Kcat = 200 per sec
4. Km of an enzyme = 4 micromole and Kcat = 200 per sec

Ans. 3) Km of an enzyme = 2 micromole and Kcat = 200 per sec

Q25. What does IDA stand for and how is it interpreted in the medical field?

1. Low serum ferritin
2. Low transferrin saturation
3. Increased TIBC
4. All of the above

Ans. 4) All of the above

If you wish to access the detailed explanations for the correct and incorrect options of Last 5 Years PYQs INI-CET Biochemistry download the Pdf now.

To scale up your INI-CET Exam preparation with the best-in-class video lectures, QBank, mock tests, and more, download the PrepLadder App!

Download PrepLadder's INI-CET preparation app for Android

Download PrepLadder's INI-CET preparation app for iOS