Last 5 Year PYQs in Biochemistry for NEET PG

Q1. What is the function of the proteasome?

1. Protein folding
2. Pot-translation modification
3. Protein degradation
4. Protein sorting

Ans. 3) Protein degradation

Q2. Replacing alanine by which amino acid, will increase the UV absorbance of protein at 280nm wavelength?

1. Leucine
2. Proline
3. Arginine
4. Tryptophan

Ans. 4) Tryptophan

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Q3. Which of the following contains the maximum amount of vitamin B12?

1. Animal products
2. Green leafy vegetables
3. Roots and tubers
4. Vegetarian diet

Ans. 1) Animal products

Q4. Which of the following is involved in the synthesis of apolipoprotein B48?

1. RNA alternate splicing
2. RNA editing
3. DNA editing
4. RNA interference

Ans. 2) RNA editing

Q5. In a patient with obstructive jaundice, which of the following outcomes may be observed in Van der Bergh's reaction?

1. Direct positive
2. Indirect positive
3. Both positive
4. Coproporphyrin

Ans. 1) Direct positive

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Q6. A patient presented with symptoms of delayed adaptation to vision in dark places, gritty sensation in the eyes, dry eyes, and softening of the cornea. What is the likely deficiency in this case?

1. Retinoic acid
2. Riboflavin
3. Niacin
4. Pantothenic acid

Ans. 4) Pantothenic acid

Q7. You are conducting an experiment on mitochondrial respiration. You add malate/pyruvate and respiration is normal. You add succinate and respiration is normal. When you add another substance in the presence of pyruvate/succinate and malate, respiration is blocked. Which of the following substances is most likely added?

1. Rotenone
2. Antimycin A
3. Oligomycin
4. 2,4-dinitrophenol

Ans. 3) Oligomycin

Q8. What could be the possible diagnosis for a patient who exhibited tendon xanthomas, with his lipid profile indicating serum cholesterol levels of 283 mg/dL and serum LDL levels of 202 mg/dL, and subsequently initiated on lovastatin treatment?

1. Familial hypercholesterolemia
2. Tangier’s disease
3. Lipoprotein lipase deficiency
4. Familial hyperchylomicronemia

Ans. 1) Familial hypercholesterolemia

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Q9. Which of the following glycosaminoglycans (GAGs) are responsible for corneal transparency?

1. Keratan sulfate
2. Chondroitin sulfate
3. Heparin sulfate
4. Hyaluronic acid

Ans.1) Keratan sulfate

Q10. In this scenario, what is the origin of the blood glucose measured at 7 am the following morning for an individual who had dinner at 8 pm the previous night?

1. Hepatic glycogenolysis
2. Hepatic gluconeogenesis
3. Muscle glycogenolysis
4. Dietary glucose

Ans. 1) Hepatic glycogenolysis 

Q11. In a patient who hails from a Mediterranean country and travels to Africa, they contract malaria. After receiving treatment with primaquine, the patient subsequently develops hemolytic anemia. Which pathway deficiency in the enzyme could potentially be responsible for this condition?

1. Glycolysis
2. Gluconeogenesis
3. Hexose monophosphate (HMP) pathway
4. Luebering-Rapoport pathway

Ans. 3) Hexose monophosphate (HMP) pathway

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Q12. Which of the subsequent disorders exhibits an autosomal recessive inheritance pattern?

1. Huntington’s disease
2. Treacher collins syndrome
3. Cystic fibrosis
4. Achondroplasia​

 Ans. 3) Cystic fibrosis

Q13. Which of the options aids in the transportation of fatty acids through the inner mitochondrial membrane?

1. Acyl carrier protein
2. Carnitine
3. Lecithin-cholesterol acyltransferase
4. Albumin

Ans. 2) Carnitine

Q14. What is the term for a single mutation in a nucleotide base pair that leads to the formation of a termination codon?

1. Missense mutation
2. Nonsense mutation
3. Stop mutation
4. Silent mutation

 Ans. 2) Nonsense mutation

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Q15. Which process is responsible for DNA packaging?

1. Histone
2. Glycoprotein
3. Nucleic acid
4. Adenine

Ans. 1) Histone

Q16. ​Which of the subsequent diseases demonstrate autosomal recessive inheritance?

1. Albinism
2. G6PD deficiency
3. Marfan’s syndrome
4. Lesch-Nyhan syndrome

Ans. 1) Albinism

Q17. Which of the following deficiencies leads to an elevation of glutamine levels in the bloodstream?

1. Arginosuccinate lyase
2. Alpha-galactosidase-A
3. Ornithine transcarbamoylase
4. Arginase

Ans. 3) Ornithine transcarbamoylase

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Q18. Which amino acid is essential for the conversion of nor-epinephrine to epinephrine among the following options?

1. Tyrosine
2. Tryptophan
3. Phenylalanine
4. Methionine

Ans. 4) Methionine

Q19. In cerebrohepatorenal syndrome, an infant exhibits symptoms of hypotonia and seizures. The condition is characterized by the accumulation of which substance in the brain?

1. Glucose
2. Long chain fatty acid
3. Lactic acid
4. Triglycerides

Ans. 2) Long chain fatty acid

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Q20. Which substrate of the Krebs cycle is diminished by an excess amount of ammonia?

1. Malate
2. Oxaloacetate
3. Fumarate
4. Alpha ketoglutarate

Ans. 4) Alpha ketoglutarate

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