Pathology Important Topics for NEET PG 2025

If you are a NEET PG 2025 aspirant, you must be aware that Pathology is not a subject that you can afford to take lightly.

From understanding the basic mechanisms of disease to mastering diagnostic concepts, Pathology forms the foundation of clinical medicine. If you have a strong grip on pathology, you are sure to score better in the exam and also improve your performance in related subjects like Medicine, Microbiology, and Pharmacology.

The only challenge that the students face while studying Pathology is its vastness. There is so much to revise =, and not everything holds equal weight in the exam.

To make it a whole lot easier for you, we have compiled a list of the most important topics in pathology for NEET PG 2025. This blog is solely written so you don’t have to second-guess what to revise. Every topic mentioned here has been handpicked based ion recent exam trends, previous year questions, and its relevance to clinical practice.

Whether you're just starting out or revising in your final lap, use this blog as a one-stop reference to ensure you're covering the most scoring areas first. The goal is simple—to help you study smart, not just hard.

So dive in, mark the topics you've mastered, highlight the ones you need to revisit, and make every hour of study count.

Your Pathology revision starts here.

Cell Injury

Cell Injury

• Insight of Cell Injury
• Types of Cell Injury
• Reversible Cell Injury
• Failure of Na+ K+ ATPase Pump 
• Anaerobic Glycolysis3.3 Decrease in Protein Synthesis
• Irreversible Cell Injury 
• Nuclear Changes in the Cell Injury: 
• Cell Death - Necrosis
• Definition
• Microscopic Examination
• Types of Necrosis 
• Cell Death - Apoptosis 
• Definition
• ATP Usage
• Inflammation
• Examples of Apoptosis
• Caspase
• Mechanism of Apoptosis 
• Efferocytosis
• Defects in Efferosome
• Update Robbins 10e- 
• Identification of Apoptosis

Also read: Important Topics in Surgery for NEET-PG

Newer Cell Deaths

• Newer Cell Deaths
• Mechanism of Necroptosis
• Pyroptosis
• Anoikis
• Cell Injury - Cellular Adaptations
• Atrophy
• Metaplasia

Intracellular Accumulations

• Pigment
• Melanin Stain 
• Hemosiderin
• Lipofuscin or Lipochrome
• Certain Criteria Regarding Pigments
• Lipids
• Stains for Lipids 
• Protein 
• Glycogen
• Calcification 
• Stains for Calcium

Autophagy and Free Radical Injury

• Types of Autophagy
• Macro-Autophagy
• Micro Autophagy
• CMA
• Mitophagy
• Cellular Ageing
• Telomere Shortening 
• Premature Ageing 
• Free Radical Injury
• Free Radical
• Free Radical Formation
• Free Radical Injury - Protection
• Ferroptosis

Inflammation

Acute Inflammation

• Cardinal Signs of Inflammation
• Sir Rudolf Virchow
• Classification of Inflammation
• Based on Fluid Type
• Based on Duration
• Events of Acute Inflammation
• Vascular Events
• Cellular Events 
• Frustrated Phagocytosis
• NETS (Neutrophil ExtracellularTraps)/Beneficial Suicide
• Emperipolesis 
• Entosis (Non-Macrophage Cell) 
• Inflammation - Clinical Correlation
• LAD (Leukocyte Adhesion Defect)
• Bruton's Hypogammaglobulinemia
• Chediak Higashi Syndrome
• Chronic Granulomatous Disease

Inflammation - Mediators

• Classification
• Cell-Derived
• Preformed Mediators 
• Newly Synthesized Mediators
• Platelet-Activating Factors (PAF)
• Chemokines
• Cytokines 
• AA Metabolites
• COX 
• LOX (Lipo Oxygenase)
• Cytochrome P450 Epoxygenase
• Iso Eicosanoid
• Plasma Derived Mediators
• Complement System
• Clotting System
• Kinin System

Chronic Inflammation Granuloma and Wound Healing

• Chronic Inflammation
• Types of Cells
• Macrophages
• Names of Macrophages in Different Organs 
• Granulomatous Inflammation
• Components of Granuloma
• Types of Giant Cells 
• Causes of Granulomas
• Wound Healing
• Events of Wound Healing

Genetics

Genetics Introduction and Mendelian Disorders

• Genetic Disorders
• Multifactorial
• Mendelian Disorders 
• AD (Autosomal Dominant) 
• AR (Autosomal recessive) 
• Enzyme Deficiency from Biochemistry
• XLR 
• XLD 
• Y-linked / Holandric Inheritance
• EDS (Ehlers-Danlos Syndrome)

Non Mendelian and Chromosomal Disorders

• Non-Mendelian Disorders
• Mitochondrial Inheritance 
• Examples of Common Mitochondrial diseases 
• Rare Case Of Mitochondrial Diseases
• Heteroplasmy
• Trinucleotide Repeat Disorders
• Intron ornon-coding region
• Exon or coding region
• Fragile X Syndrome 
• Myotonic dystrophy (CTG repeats) 
• Genomic Imprinting (Gene Silencing) 
• Clinical Features
• Gonadal Mosaicism / Germline Mosaicism
• Chromosomes
• Types of Chromosomes
• Structural Disorders
• Down's Syndrome (Trisomy 21) 
• Pathogenesis
• Clinical features
• Complications of Down's syndrome
• Testing of Down's Syndrome
• Edward's Syndrome: Trisomy 18
• Patau Syndrome: Trisomy 13
• Cat Eye vs Cat Cry
• Klinefelter Syndrome
• Turner's Syndrome (Monosomy) 
• Clinical Features 
• Noonan Syndrome

Diagnosis of Genetic Disorders

• Pedigree Analysis
• Rules 
• Karyotyping
• Steps Involved 
• FISH (Fluorescent Insitu Hybridisation) 
• PCR
• CGH (Comparative Genomic Hybridization)
• MLPA(Multiplex Ligation dependent Probe Amplification)

Miscellaneous Concepts in Genetics

• Lyon's Hypothesis
• Knock Down and Know Out Technology
• Dicer Mutation
• Knock Out Technology
• Epigenetics (Above Genetics)

Neoplasia

Classification of Neoplasia

• Classification of Neoplasms
• Features of Neoplasia
• One Liners
• Anaplasia 
• Dysplasia and Anaplasia 
• Rate of Growth
• Local Invasion and Metastasis
• Pathways of Metastasis
• Lymphatic Spread - Sentinel LN
• Tumors Showing Bony Metastasis

Fundamentals of Neoplasia 

• Self-sufficiency of growth signals
• Growth Factor Receptor Mutations
• Signal Transduction Protein Mutations
• Nuclear Transcription Factors Mutation
• Cell Cycle Phases
• Cell Cycle Progression (Smooth phase-to-phase transmission)
• Cell Cycle Mutation
• Tumor Suppressor Genes
• Normal Functions 
• p53 Disease 
• RB Gene
• RB Gene Mutation
• APC Gene
• PTEN Gene
• CDH1 Gene
• Limitless replicative potential
• Evasion from apoptosis
• Angiogenesis
• Invasion and metastasis
• Driver mutation VS passenger mutation
• DNA Repair Defects
• Warburg Effect 
• Escape Immune Surveillance 

Etiology of Neoplasia

• Radiation Carcinogenesis 
• Chemical Carcinogenesis 
• Metals
• Microbial Carcinogenesis
• Fungal
• Parasitic
• Viral 
• Cancer in EBV

Diagnosis of Tumors and Paraneoplastic Syndrome

• Tumor Markers
• FNAC: Fine Needle Aspiration Cytology
• FNNAC: Fine Needle Non-Aspiration Cytology
• Contraindications of FNAC
• FNAC Pitfall
• Biopsy
• Immunohistochemistry
• Immunohistochemistry Markers
• IHC Sarcoma
• IHC Carcinoma: CK7 and Ck20
• Merkel Cell Carcinoma
• Paraneoplastic Syndrome: PNS
• PNS Table 
• Miscellaneous Topics with New Updates
• Liquid Biopsy
• Chimeric Antigen T cell: CART Therapy
• Epigenetics in Cancer

Immunity

Types of Immunity

• Types of Immunity
• Components of Innate Immunity
• Natural Killer Cells (NK Cells) 
• Antibody-Dependent Cellular Cytotoxicity (ADCC)
• Pattern Recognition Receptors
• Update—Interferonopathies
• Acquired Immunity
• Cellular Immunity - B and T Cells
• Lymph Node
• Spleen
• GIT
• T Cells 
• B Cells
• Interaction between B and T Cells 
• Humoral Immunity
• Activation of Cells
• Major Histocompatibility Complex (MHC)
• Difference Between MHC I and MHC II 
• Types of T Cells

Types of Hypersensitivity Reactions

• Immunity - Hypersensitivity Reactions 
• Type I Hypersensitivity Mechanism
• Type II Hypersensitivity Mechanisms 
• Type III Hypersensitivity – Phases
• Type IV Hypersensitivity 
• Type V Hypersensitivity – Examples
• Controversial Hypersensitivity

Tolerance And Autoimmune Disorders

• Central Tolerance
• Deletion/negative selection
• Receptor editing
• Peripheral Tolerance
• Killing of self-reactive cells
• Anergy
• Cryptic/Hidden Antigen
• Autoimmune Disorders 
• Other organs affected by SLE
• Drug-Induced Lupus (DIL)
• Sjogren syndrome
• Scleroderma
• Mixed Connective Tissue Disorder
• Myositis

Immunodeficiency Disorders

• Types of immunodeficiency
• Primary Immunodeficiency
• Defect in Lymphocyte maturation 
• Systemic disease

Transplant Immunology

• Pre-Transplant
• Types of Grafts 
• Prior to Transplantation
• Post-Transplant
• Transplant Rejection 
• Graft Versus Host Disease 

Amyloidosis

• Primary Amyloidosis
• Secondary Amyloidosis 
• Gross findings – Amyloidosis

Cvs, Blood Vessels And Vasculitis

Vasculitis

• Blood Vessels
• Appearance
• Weibel Palace Bodies
• Vasculitis
• Large Vessel Vasculitis
• Medium Vessel Vasculitis 
• Small Vessel Vasculitis
• ANCA Association
• Behcet's Disease
• Blood Vessels- Sclerosis
• Hyaline Arteriolosclerosis
• Hyperplastic Arteriolosclerosis
• Monckeberg's Sclerosis
• Atherosclerosis
• Aortic Dissection
• Vascular Tumors- Classification
• Malignant 

Cardiac Pathology

• Various cardiac disorders
• Heart Failure
• Ischemic Heart Disease 
• Updates: Earlier Cardiac Markers

Carditis and Cardiac Tumors

• Pericarditis
• Myocarditis 
• Endocarditis 
• Cardiomyopathy
• Cardiac Tumours

Respiratory System

Lung Pathology

• Basic Anatomy of Lungs
• Histology of Lungs
• Congenital Abnormalities
• Obstructive Pulmonary Disease
• COPD
• Asthma
• Bronchiectasis
• Restrictive Lung Diseases
• Fibrosing Diseases 
• Granulomatous Diseases 
• Pneumoconiosis
• Tuberculosis
• Pulmonary Hypertension
• Primary Pulmonary Hypertension
• Secondary Pulmonary Hypertension
• ARDS 
• Pathogenesis
• Lung Tumor
• Adenocarcinoma
• Small Cell Carcinoma
• Pleural Tumors

Salivary Gland

Salivary Gland Pathology

• Histology of Salivary Glands
• Salivary Gland Tumors
• Benign Tumors
• Malignant Tumors

Gastrointestinal Tract

GIT

• Parts of GIT
• Layers of GIT
• Pacemaker Cells
• Esophagus
• Achalasia Cardia / Mega Esophagus 
• Diagnostic modalities
• Esophagitis
• Infective Esophagitis
• Eosinophilic Esophagitis
• Alcohol-Induced Lacerations
• Mallory Weiss Syndrome
• Boerhaave syndrome
• Mackler's triad
• Barrett's Esophagus 
• Clinical Features
• Endoscopy
• Esophageal Tumors
• Carcinoma
• Risk Factors of Squamous Cell Carcinoma
• Risk Factors of Adenocarcinoma
• Gold Standard forDiagnosis of Esophageal Carcinoma
• Stomach
• Gastritis
• Peptic Ulcer Disease
• Gastric Outlet Obstruction
• Menetrier's Disease
• Zollinger Ellison Syndrome (ZES) 
• Gastric Tumors
• Gastrointestinal Stromal Tumor
• Gastrointestinal Pathology – Intestine
• Malabsorption Syndrome
• Ulcerative disorders
• Ulcerative Disorders 
• Inflammatory bowel disease 
• Treatment 
• Polyps - Classification
• Hamartomatous Polyps 
• Neoplastic: Adenomas
• FAP- Familial Adenomatous Polyposis 
• Mutyh Associated Polyposis (MAP)
• Intestinal Carcinoma
• Risk Factors
• Mechanisms
• Anal Canal Cancer
• Miscellaneous Tumor: Carcinoid Tumor
• Carcinoid Syndrome
• Enterobius Vermicularis
• Diagnosis of Appendicitis

Liver, Biliary System And Pancreas

Hepatobiliary Pathology

• Space of Disse
• Sinusoids
• Canals of herring
• Bilirubin Metabolism
• Testing of bilirubin
• Hyperbilirubinemia / Jaundice 
• Onion Skinning in Pathology (Recap)

Liver Cirrhosis , Tumors and Miscellaneous Topics

• Cirrhosis - Definition
• Cirrhosis – Features 
• Micronodular Cirrhosis
• Macronodular Cirrhosis
• Biliary Cirrhosis
• Causes of Cirrhosis
• Alcoholic Liver Disease
• Non-Alcoholic Liver Disease
• Autoimmune Hepatitis
• Hemochromatosis
• Wilson's Disease 
• Viral Hepatitis 
• Hepatic Tumors
• Hepatic Tumor - Benign
• HepatocellularCarcinoma (HCC)
• Miscellaneous Topics
• Nutmeg Liver
• Central Stellate Scar
• FNH Liver

Renal System

Renal Pathology- Introduction and Spotters

• Kidney- Functional Unit
• Gross Appearances of the Kidney
• Malakoplakia 
• Polycystic Kidney Disease(PCKD) 
• Medullary Cystic Kidney
• Medullary Sponge Kidney
• Urine Examination 

Nephritic and Nephrotic Syndrome

• Nephritic Syndrome 
• Post-Streptococcal Glomerulonephritis (Hypersensitivity III) 
• IgA Nephropathy/ Berger's Disease
• Rapidly Progressive Glomerulonephritis 
• Good pasture Syndrome/Anti Glomerular Basement Membrane Ab Disease
• Thin Basement Membrane Disease (<200 nm thin)
• Alport Syndrome
• Nephrotic Syndrome 
• Minimal Change Disease / Lipoid Nephrosis / Nil Deposit Disease
• Focal Segmental Glomerulosclerosis
• Membranous Glomerulonephropathy (MGN)
• MPGN (Membranoproliferative Glomerulonephritis) 
• SLE- Lupus Nephritis 
• Diabetic Nephropathy 
• Kimmelstein Wilson Lesion 
• Renal Papillary Necrosis

Renal Pathology Tumors

• Classification
• Renal Oncocytoma
• Angiomyolipoma (AML) 
• Wilm's Tumor

Genital System

Pathology of Female Genital Tract

• Vulval tumor
• Vaginal Tumor
• Cervical Cancer
• Infections
• Endometrium
• Gestational trophoblastic tumor

Pathology of Male Genital Tract

• Penile Tumors
• Testes 
• Testicular Tumors – Classification
• Precursor or Risk Factors
• Role of FNAC
• Non Germ Cell Tumours
• Prostate Gland
• Gleason Grading System

Breast Pathology

Breast Pathology

• TDLU (Terminal duct lobular unit)
• Glands of Breast Tissue
• Markers
• Inflammatory Disorders or Lesions
• Lesions of the Breast
• Fibrocystic Diseases
• Proliferative Breast Diseases without Atypia
• Proliferative Breast Diseases with Atypia

Breast Tumors

• Classification of breast tumors 
• Stromal Tumors
• Breast Cancer
• Epidermal Tumors 
• Molecular Classification of Breast Cancer
• Modified Bloom Richardson Scoring

Central Nervous System

Basics of Central Nervous System

• Cells of the Central Nervous System
• Glial Cells
• Macrophages
• Prion Diseases
• Neuro-degenerative Disorders 
• Parkinson's Disease
• Huntington's Disease 
• Amyotrophic Lateral Sclerosis
• Proteins & Diseases

Brain Tumors

• Primary Brain Tumors - Grading
• Classification of Brain Tumors
• Gliomas- Gilal cells 
• Neuronal Tumors
• Undifferentiated Tumors
• Meningioma

Endocrinology

Thyroid Gland & Tumor Pathology

• Endocrine Pathology - Thyroid Gland
• Normal Thyroid 
• Hashimoto's Thyroiditis/Struma Lymphomatosum 
• De Quervain Thyroiditis
• Subacute Lymphocytic Thyroiditis
• Riedel's Thyroiditis
• Hyperthyroidism
• Graves' Disease / Basedow Disease
• Thyroid Tumors
• Hurthle Cell Adenoma
• Toxic Adenoma
• Thyroid Carcinoma
• Papillary Carcinoma 
• Medullary Thyroid Carcinoma

Parathyroid, Adrenal & Pituitary Gland

• Parathyroid Gland
• Histology of Parathyroid Gland
• Physiology of Parathyroid Gland
• Hyperparathyroidism
• Secondary hyperparathyroidism
• Tertiary Hyperparathyroidism
• Hypoparathyroidism
• Adrenal Gland Tumors
• Neuroblastoma
• Pheochromocytoma 
• Pituitary Gland
• MEN Syndrome

Bone Disorders

Bone and Soft Tissue Pathology

• Normal Bone and Bone Marrow
• Bone Trabeculae
• Bone Tumors
• Bone Forming Tumors
• Cartilage Forming Tumors
• Indeterminate 
• Undifferentiated 
• Tumor-Like Conditions
• Soft Tissue Tumors
• Fat Tumor

Skin And Musculoskeletal

Skin Pathology

• Layers of Epidermis
• Hyperkeratosis
• Parakeratosis
• Ichthyosis
• Psoriasis
• Lichen Planus
• Seborrheic Keratosis
• Skin Appendageal Tumors
• Cylindroma
• Pilomatrixoma
• Syringoma
• Trichilemmomas
• Molluscum Contagiosum 
• Bullous Disorders
• Pemphigus 
• Bullous Pemphigoid
• Epidermolysis Bullosa Acquisita (EBA)
• Dermatitis Herpetiformis
• Hailey - Hailey Disease
• Carcinomas of Skin
• Squamous Cell Carcinomas
• Basal Cell Carcinoma 
• Malignant Melanoma
• Cutaneous Leishmaniasis
• Langerhans Cells Histiocytosis

Hematology : Red Blood Cells

Skin Pathology

• Hematology
• Bone Marrow Basics
• Salah and Klima Needle 
• Bone Marrow Biopsy Processing
• Dry Tap
• Stains
• Erythropoiesis 
• Reticulocyte Count
• Corrected Reticulocyte Count
• Reticulocyte Production Index (RPI)
• Miller Disc Method of Counting
• RBC Indices
• Westergren Pipette: ESR
• Micro Hematocrit
• Stages of ESR (Erythrocyte Sedimentation Rate - 60 minutes)
• MCV, MCH, MCHC
• RDW (Red Cell Distribution Width)
• Peripheral SmearAnalysis
• Poikilocytosis

Microcytic Hypochromic Anaemia

• Iron Deficiency Anemia
• Iron Metabolism
• Iron Transportation 
• Iron Absorption 
• Master Regulator of Iron
• Causes of IDA
• Stages of IDA
• Clinical Presentations
• Blood Findings
• Iron Studies
• Normal Values
• Bone Marrow Studies
• Treatment
• Anemia of Chronic Disease (AOCD) 
• Profile of AOCD Varying from IDA 
• Sideroblastic Anemia

Macrocytic Hypochromic Anaemia

• Associated with LHMC
• Megaloblastic Anemia
• Vitamin B12
• Schilling Test
• Folate Metabolism and Deficiency

Hemolytic Anemias

• IVH (Intravascular Hemolysis) 
• EVH (Extravascular Hemolysis)
• Classification
• Intracorpuscular Defects
• Hereditary spherocytosis (HS)
• Pathogenesis of HS
• Clinical features of HS 
• Confirmatory tests for HS
• Treatment for HS
• G6PD deficiency 
• Pathogenesis of G6PD Deficiency
• Diagnosis of G6PD Deficiency
• Clinical Features of G6PD Deficiency
• Acquired - PNH (Paroxysmal Nocturnal Hemoglobinuria) 
• Pathogenesis of PNH 
• Clinical Features of PNH
• Complications of PNH
• Treatment for PNH

Sickle Cell Anemia and Thalassemia

• Sickle Cell Anemia 
• Factors resulting in sickle cell anemia
• Types
• Pathophysiology
• Clinical Features of Sickle Cell Anemia
• Other Crises of Sickle Cell Anemia
• Diagnosis of Sickle Cell Anemia
• Thalassemia 
• β Thalassemia 
• α Thalassemia

Autoimmune Hemolytic Anemia

• Warm AIHA
• Cold AIHA
• Hypoproliferative Anemias 
• PRCA (Pure Red Cell Aplasia) 
• Myelophthisic Anemia

RBC Shapes and Inclusions

• Pencil cells
• Spherocytes
• Degmacytes
• Drepanocytes
• Dacrocytes
• Schistocytes
• Acanthocytes
• Echinocytes
• Codocytes
• Agglutination of RBCs
• Rouleaux Formation
• Crystal form
• Pincer Cells
• Cabot Ring

Hematology : White Blood Cells

Basics of WBC

• Myelopoiesis
• Cell Count 
• Diseases of WBC

Leukemia and Lymphoma 

• Difference between Leukemia and Lymphoma
• Leukemia
• ALL- Acute Lymphoblastic Leukemia 
• AML- Acute Myeloid Leukemia 
• Chronic Lymphocytic Leukemia 
• CLL- Clinical Features
• CLL- Diagnostic Criteria 
• CLL- Staging
• Chronic Myeloid Leukemia
• CML- Genetics 
• CML- Clinical Features
• Treatment
• LAP/ NAPScore
• Lymphoma
• Difference between Hodgkin's and Non-Hodgkin's Lymphoma
• Hodgkin's Lymphoma 
• Types of Hodgkin's Lymphoma
• Types of Classical Hodgkin's Lymphoma
• Types of Non-Classical HL
• Non-Hodgkin's Lymphoma 
• Follicular Lymphoma 
• Diffuse Large B cell Lymphoma
• Burkitt's Lymphoma
• Mantle Cell Lymphoma
• Marginal Zone Lymphoma / Maltoma
• Hairy Cell Leukemia 
• T- NHL

Chronic Myeloproliferative Disorder and Myelodysplastic Syndromes

• Polycythemia Vera 
• Essential Thrombasthenia
• Primary Myelofibrosis 
• Myelodysplastic Syndrome (MDS)

Plasma Cell Dyscrasia

• Disorders
• Multiple Myeloma - Genetics 
• Smouldering Multiple Myeloma - Criteria
• Monoclonal Gammopathy of Undetermined Significance - Criteria (MGUS)
• Plasma Cell Leukaemia – Criteria
• Waldenstrom's Macroglobulinemia (IgM)
• Heavy Chain Disease

Flow Cytometry

• Types of Graphs in Flow Cytometry

Platelet And Bleeding Disorders

Platelet (Coagulation and Bleeding Disorders)

• Platelets
• Defects in Megakaryocytes
• Clot Formation
• Clotting Pathway
• Tests
• Bleeding Disorders
• Platelet Defects
• Clotting Factors Defects 
• Thrombotic Microangiopathy 

Platelets (Mixing Studies)

• Special Tests
• Mixing Studies
• Platelet Aggregometry
• Thromboelastography (TEG)

Blood Banking and Transfusion Medicine

Blood Banking and Transfusion Medicine 

• Blood Group Genetics 
• Bombay Blood Group/Bhende ET AL
• Lewis Blood Group
• Kell Blood Group
• Duffy Antigen 
• P antigen And I Antigen
• Rh Antigen
• Blood Grouping Methods
• Blood Donation
• Preservatives / Anticoagulants
• Washed RBC
• Screening for TTI (Transfusion Transmitted Infection) 
• Transfusion Protocols 
• Massive Blood Transfusion (MBT) 
• Transfusion Reactions
• Autologous Blood Transfusion
• Apheresis Machine

Miscellaneous

Tissue Processing

• Steps Involved in Tissue Processing
• Fixation
• Dehydration
• Clearing
• Impregnation
• Embedding and Blocking
• Section Cutting
• Routine Staining

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