Rabies Virus Transmission: An Exploration of Neurons

First of all, The rabies virus uses a highly developed technique to enter the nervous system. It is well-known for its capacity to induce severe neurological symptoms. This blog article explores the intriguing realm of cellular transport mechanisms, with a particular emphasis on the function of dynein in mediating the viral dissemination of rabies in neurons.

Comprehending Anterograde Transporter Kinesin

Because it transports cargo towards the plus end of microtubules, which is usually towards the cell periphery, kinesin is frequently referred to as the "anterograde transporter." Think of kinesin as a molecular courier that transports important goods to specific sites within the cell, including proteins, vesicles, and organelles.

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Comprehending Dynein and Retrograde Transport

 Within cells, microtubule-based retrograde transport is facilitated by the motor protein dynein. Cargo is moved toward the negative end of microtubules, usually in the direction of the cell body. Use the DR-AK mnemonic (Dynein-Retrograde transport and Antegrade transport-Kinesin) to help you remember this.

Hijacking Dynein

Cellular subversion is nothing new for the rabies virus. By engaging with particular cellular receptors and entering neurons through endocytic pathways, it takes control of the dynein motor machinery. Once inside the neuron, endosomal vesicles surround the virus.

The Microtubule Highway leads to the central nervous system, where dynein motor proteins arrange an amazing voyage. Microtubules carry the rabies virus-containing endosomal vesicles toward the direction of the cell body. The virus's advancement towards the central nervous system (CNS), where it can cause severe neurological symptoms, depends on this retrograde movement.

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Dynein Regulation and Neurodegenerative Disorders

 Dynein is essential for preserving the health of neurons and is not just used in viral hijacking. A regulatory protein called dynactin makes sure that dynein operates as it should. Neurodegenerative diseases like Parkinson's, Alzheimer's, Huntington's, and motor neuron diseases are characterized by disruptions in axonal transport, including dynein dysregulation.Oms.

In summary the complex interaction between the rabies virus and dynein in neurons reveals the remarkably complex nature of cellular transport pathways. This trip sheds light on the wider ramifications of dynein dysregulation in neurodegenerative illnesses in addition to offering insights into viral pathogenesis. It is hoped that as scientists work to solve these puzzles, new therapeutic approaches in the field of neurology will be made possible.

Also Read: High-yield NEET SS Medicine Neurology Questions

Hope you found this blog helpful for your NEET SS Medicine Neurology Preparation. For more informative and interesting posts like these, keep reading PrepLadder’s blogs.